SCHEMBL14759596

SCHEMBL14759596

CCCCCCCCCCCCCC[C]CCCCCCCCCCCCCC

nearest known ligand 0.57

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.57
THRB P10828 1/20 0.57
PTPN7 P35236 3/20 0.42
HMGCR P04035 1/20 0.42
DNM1 Q05193 5/20 0.42
ALDH1A1 P00352 2/20 0.42
LMNA P02545 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HSD17B10 Q99714 1/20 0.42
SLC22A1 O15245 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14759630 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL14759610 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL14760261 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL3697613 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL3199000 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL3695352 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL10631303 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL11579416 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL6745588 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1
SCHEMBL3211092 1.00 TSHR (0.57) TSHRTHRBPTPN7HMGCRDNM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130129811-A1 CATIONIC LIPID KYOWA HAKKO KIRIN CO., LTD. (JP) 2013-05-23 US claimed
EP-2567952-A1 CATIONIC LIPID Kyowa Hakko Kirin Co., Ltd. (JP) 2013-03-13 EP claimed
EP-2567951-B1 CATIONIC LIPID KYOWA HAKKO KIRIN CO LTD (JP) 2018-09-19 EP disclosed
EP-3301086-A1 PRODUCTION OF A COMPOSITION CONTAINING A COMPLEX BETWEEN A MEMBRANE COMPOSED OF A LIPID MONOLAYER AND A NUCLEIC ACID, AND, A LIPID MEMBRANE FOR ENCAPSULATING THE COMPLEX THEREIN Kyowa Hakko Kirin Co., Ltd. (JP) 2018-04-04 EP disclosed
US-9920028-B2 Cationic lipid KYOWA HAKKO KIRIN CO., LTD. (JP) 2018-03-20 US disclosed
US-9845306-B2 Cationic lipid KYOWA HAKKO KIRIN CO., LTD. (JP) 2017-12-19 US disclosed
US-20170349532-A1 CATIONIC LIPID KYOWA HAKKO KIRIN CO., LTD. (JP) 2017-12-07 US disclosed
US-20160304487-A1 CATIONIC LIPID KYOWA HAKKO KIRIN CO LTD (JP) 2016-10-20 US disclosed
US-9408914-B2 Cationic lipid KYOWA HAKKO KIRIN CO., LTD. (JP) 2016-08-09 US disclosed
US-20150343062-A1 CATIONIC LIPID KYOWA HAKKO KIRIN CO LTD (JP) 2015-12-03 US disclosed
EP-2792368-A1 LIPID NANOPARTICLES CONTAINING COMBINATIONS OF CATIONIC LIPIDS Kyowa Hakko Kirin Co., Ltd. (JP) 2014-10-22 EP disclosed
EP-2774912-A1 CATIONIC LIPID Kyowa Hakko Kirin Co., Ltd. (JP) 2014-09-10 EP disclosed
US-20140045913-A1 LIPID NANO PARTICLES COMPRISING COMBINATION OF CATIONIC LIPID KYOWA HAKKO KIRIN CO., LTD. (JP) 2014-02-13 US disclosed
US-20130280305-A1 CATIONIC LIPID KYOWA HAKKO KIRIN CO., LTD. (JP) 2013-10-24 US disclosed
US-20130129811-A1 CATIONIC LIPID KYOWA HAKKO KIRIN CO., LTD. (JP) 2013-05-23 US disclosed
US-20130108685-A1 CATIONIC LIPID KYOWA KIRIN CO., LTD. (JP) 2013-05-02 US disclosed
EP-2567952-A1 CATIONIC LIPID Kyowa Hakko Kirin Co., Ltd. (JP) 2013-03-13 EP disclosed
EP-2567951-A1 CATIONIC LIPID Kyowa Hakko Kirin Co., Ltd. (JP) 2013-03-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160304487-A1 CATIONIC LIPID LPAR3, ACOX3, H1-3 TSHR 2021/4885THRB 2391/4885PTPN7 3656/4885
US-20140045913-A1 LIPID NANO PARTICLES COMPRISING COMBINATION OF CATIONIC LIPID LPAR3, APOL1, PLIN3 TSHR 1449/4885THRB 3416/4885PTPN7 2055/4885
US-20170349532-A1 CATIONIC LIPID LPAR3, ACOX3, H1-3 TSHR 2021/4885THRB 2391/4885PTPN7 3656/4885
US-20130108685-A1 CATIONIC LIPID LPAR3, ACOX3, H1-3 TSHR 2021/4885THRB 2391/4885PTPN7 3656/4885
US-20130280305-A1 CATIONIC LIPID LPAR3, ACOX3, H1-3 TSHR 2021/4885THRB 2391/4885PTPN7 3656/4885
US-20130129811-A1 CATIONIC LIPID ACOX3, LPCAT1, ACOX1 TSHR 1380/4885THRB 2181/4885PTPN7 3802/4885
US-20150343062-A1 CATIONIC LIPID ACOX3, LPAR3, ELOVL3 TSHR 2136/4885THRB 2699/4885PTPN7 3757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.