Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984386 | 0.82 | KDM4E (0.65) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL16586809 | 0.80 | KDM4E (0.63) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL14815244 | 0.79 | HPGD (0.40) | KDM4EHSD17B10HPGDTSHRCREBBP | |
| SCHEMBL14815430 | 0.76 | KDM4E (0.46) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL1687647 | 0.76 | HSD17B10 (0.49) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL17075223 | 0.74 | KDM4E (0.48) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL14815485 | 0.74 | HSD17B10 (0.48) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL1687637 | 0.73 | KDM4E (0.43) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL10049228 | 0.73 | KDM4E (0.43) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL2455124 | 0.71 | KDM4E (0.44) | KDM4EHSD17B10HPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9837622-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20150263297-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| EP-1960402-B1 | NOVEL IMIDAZOQUINAZOLINE DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND ORGANIC ELECTRONIC DEVICE USING THE SAME | LG CHEMICAL LTD (KR) | 2013-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150263297-A1 | Metal Complexes | SOD1, AP1M1, AP3M1 | KDM4E 3816/4885HSD17B10 2888/4885HPGD 3882/4885 |
| US-20130082209-A1 | METAL COMPLEXES | MCOLN2, MCOLN1, AP1M1 | KDM4E 4129/4885HSD17B10 3651/4885HPGD 3092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.