Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.44 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9277706 | 0.83 | KMT2A (0.46) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| SCHEMBL18708623 | 0.82 | EED (0.47) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| SCHEMBL2585402 | 0.81 | MEN1 (0.47) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL2591808 | 0.80 | MEN1 (0.46) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| SCHEMBL2591527 | 0.80 | KDM4E (0.58) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| SCHEMBL8123045 | 0.79 | MDM2 (0.51) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| SCHEMBL9697271 | 0.78 | BCL2 (0.45) | KMT2AMEN1L3MBTL1PDE3BPDE3A | |
| SCHEMBL14716843 | 0.76 | EED (0.60) | PDE3BPDE3ALMNAEEDRBBP4 | |
| SCHEMBL14917611 | 0.75 | GRIN2D (0.46) | KMT2AMEN1L3MBTL1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL9356212 | 0.72 | ALDH1A1 (0.43) | KMT2AMEN1L3MBTL1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755962-A1 | AZAINDAZOLES | GlaxoSmithKline LLC (US) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013039988-A1 | AZAINDAZOLES | GLAX0SMITHKLINE LLC (US) | 2013-03-21 | — | — | WO | disclosed |
| EP-2566327-A1 | INDOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |