SCHEMBL1476059

SCHEMBL1476059

C#Cc1ccc(F)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.41
HDAC8 Q9BY41 2/20 0.37
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
EGFR P00533 1/20 0.36
MAP2K2 P36507 1/20 0.34
MAP2K1 Q02750 1/20 0.34
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
CA14 Q9ULX7 2/20 0.33
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33
CA4 P22748 1/20 0.33
PTPN1 P18031 2/20 0.32
GABRA1 P14867 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29524972 1.00 GRM5 (0.41) GRM5HDAC8CES2CES1EGFR
SCHEMBL24942538 0.81 CYP17A1 (0.43) GRM5HDAC8CA12CA1CA2
SCHEMBL29061357 0.81 CA3 (0.44) GRM5CES2CES1CA1CA2
SCHEMBL16182687 0.80 HDAC8 (0.34) HDAC8EGFRMAP2K2MAP2K1CA12
SCHEMBL2797870 0.78 CA9 (0.50) EGFRCA12CA1CA2CA9
SCHEMBL3456320 0.78 CA12 (0.34) HDAC8EGFRCA12CA1CA2
SCHEMBL1477519 0.78 GRM5 (0.44) GRM5HDAC8EGFRMAP2K2MAP2K1
SCHEMBL14482193 0.78 ALDH1A1 (0.34) HDAC8EGFRMAP2K2MAP2K1CA12
SCHEMBL31308753 0.78 EGFR (0.49) HDAC8EGFR
SCHEMBL15094371 0.78 EGFR (0.49) HDAC8EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008876-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2026-01-08 US claimed
WO-2025128217-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2025-06-19 WO claimed
WO-2025128218-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2025-06-19 WO claimed
WO-2025128219-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2025-06-19 WO claimed
WO-2025128220-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2025-06-19 WO claimed
WO-2025128216-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2025-06-19 WO claimed
WO-2025128214-A1 ADDITIVE FOR A CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2025-06-19 WO claimed
CN-115698105-B Chemical conversion catalyst 陶氏环球技术有限责任公司 2024-11-08 CN claimed
CN-118841221-A Low-resistance patterned conductive leather and preparation method and application thereof 厦门大学 2024-10-25 CN claimed
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US claimed
CN-111111785-B COF material supported transition metal catalyst and preparation method and application thereof 中国科学院广州能源研究所 2022-10-21 CN claimed
US-20220056167-A1 Functionalized Cyclic Polymers and Methods of Preparing Same NATIONAL SCIENCE FOUNDATION 2022-02-24 US claimed
WO-2021243145-A1 CHEMICALLY CONVERTED CATALYSTS DOW GLOBAL TECHNOLOGIES LLC (US) 2021-12-02 WO claimed
WO-2020223672-A1 FUNCTIONALIZED CYCLIC POLYMERS AND METHODS OF PREPARING SAME UNIVERSITY OF FLORIDA RESEARCHFOUNDATION, INC. (US) 2020-11-05 WO claimed
CN-111111785-A COF material supported transition metal catalyst and preparation method and application thereof 中国科学院广州能源研究所 2020-05-08 CN claimed
EP-1599201-B1 SELECTIVE NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS MERCK SHARP & DOHME (US) 2010-04-14 EP claimed
CN-1185189-C Alkyl dicyclohexyl alkyne group liquid crystal and production method thereof UNIV TSINGHUA (CN) 2005-01-19 CN claimed
CN-1450040-A Alkyl dicyclohexyl alkyne group liquid crystal and production method thereof UNIV TSINGHUA (CN) 2003-10-22 CN claimed
CN-1096449-C Process for preparing substituted arylpyrazoles BAYER AG (DE) 2002-12-18 CN claimed
EP-0771196-B1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1999-12-08 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008876-A1 ADDITIVE FOR A CATALYST HACL2, SCO2, CCNL2 GRM5 3358/4885HDAC8 3260/4885CES2 102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.