Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775197 | 0.82 | TSHR (0.32) | KMT2AMAPK1MEN1TSHRKDM4C | |
| SCHEMBL30831248 | 0.79 | NPC1 (0.36) | KMT2AALDH1A1LMNANPC1KDM4C | |
| SCHEMBL31656144 | 0.78 | MAPK1 (0.41) | MAPK1KDM4E | |
| SCHEMBL14775198 | 0.77 | BCHE (0.32) | BCHEACHEPTGS2 | |
| SCHEMBL31738488 | 0.71 | PTGS2 (0.40) | NPC1BCHEACHEPTGS2 | |
| SCHEMBL31345378 | 0.68 | NPC1 (0.38) | KMT2AALDH1A1LMNANPC1KDM4C | |
| SCHEMBL18377722 | 0.68 | NPC1 (0.46) | KMT2AMAPK1ALDH1A1LMNANPC1 | |
| SCHEMBL18377936 | 0.67 | NPC1 (0.42) | KMT2AMAPK1ALDH1A1LMNANPC1 | |
| SCHEMBL18367606 | 0.66 | NPC1 (0.41) | KMT2AALDH1A1LMNANPC1KDM4C | |
| SCHEMBL1784554 | 0.66 | HDAC3 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218612-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE | KYOWA KIRIN CO., LTD. (JP) | 2023-07-13 | — | — | US | disclosed |
| US-10548891-B2 | Nitrogen-containing heterocyclic compound having inhibitory effect on production of kynurenine | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2020-02-04 | — | — | US | disclosed |
| US-20150352106-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE | KYOWA KIRIN CO., LTD. (JP) | 2015-12-10 | — | — | US | disclosed |
| US-9150569-B2 | Nitrogen-containing heterocyclic compound having inhibitory effect on production of kynurenine | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20130065905-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352106-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE | KYNU, KMO, IDO1 | KMT2A 717/4885MAPK1 233/4885MEN1 1254/4885 |
| US-10548891-B2 | Nitrogen-containing heterocyclic compound having inhibitory effect on production of kynurenine | KYNU, KMO, IDO1 | KMT2A 717/4885MAPK1 233/4885MEN1 1254/4885 |
| US-20230218612-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE | KYNU, KMO, IDO1 | KMT2A 717/4885MAPK1 233/4885MEN1 1254/4885 |
| US-20130065905-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE | KYNU, KMO, IDO1 | KMT2A 717/4885MAPK1 223/4885MEN1 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.