Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514403 | 0.71 | KDM4E (0.41) | ACHENQO2NISCHKDM4EUSP2 | |
| SCHEMBL4488123 | 0.69 | ACHE (0.37) | BCHEACHEKDM4EALDH1A1MAPT | |
| SCHEMBL14310463 | 0.60 | — | — | |
| SCHEMBL9857769 | 0.60 | ALDH1A1 (0.41) | ACHENQO2KDM4EALDH1A1MAPT | |
| SCHEMBL7544635 | 0.59 | PLAUR (0.35) | BCHEACHENQO2ELANEKDM4E | |
| SCHEMBL10514970 | 0.58 | PLAUR (0.51) | ELANEKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4507436 | 0.57 | MAPT (0.50) | ELANEKDM4EUSP2ALDH1A1MAPT | |
| SCHEMBL11242361 | 0.57 | KDM4E (0.39) | ACHEELANEKDM4EUSP2ALDH1A1 | |
| SCHEMBL6293469 | 0.57 | — | — | |
| SCHEMBL11247647 | 0.57 | GPR3 (0.41) | BCHEACHEELANEKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033971-A1 | TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-03-14 | — | — | WO | disclosed |