Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SI | P14410 | 2/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764520 | 0.92 | MAPT (0.44) | MAPTRAB9AMAPK1PIM1PIM2 | |
| SCHEMBL31399980 | 0.88 | TDP1 (0.52) | MAPTRAB9AMAPK1TDP1DRD4 | |
| SCHEMBL2423180 | 0.88 | TDP1 (0.52) | MAPTRAB9AMAPK1TDP1DRD4 | |
| SCHEMBL4181275 | 0.84 | NR1H2 (0.43) | MAPTPIM1PIM2TDP1SRC | |
| SCHEMBL8604288 | 0.83 | MAPT (0.52) | MAPTRAB9AMAPK1SRCGAA | |
| SCHEMBL14734341 | 0.81 | PIM1 (0.40) | MAPTRAB9AMAPK1PIM1PIM2 | |
| SCHEMBL14764386 | 0.81 | ALDH1A1 (0.42) | PIM1PIM2TDP1GPR3NQO2 | |
| SCHEMBL30217825 | 0.81 | ALDH1A1 (0.42) | PIM1PIM2TDP1GPR3NQO2 | |
| SCHEMBL20475325 | 0.80 | RAB9A (0.53) | MAPTRAB9AMAPK1GAANQO2 | |
| SCHEMBL31643056 | 0.80 | RAB9A (0.53) | MAPTRAB9AMAPK1GAANQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |