Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764653 | 1.00 | CA12 (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL15912664 | 1.00 | CA12 (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL1682134 | 0.97 | FAAH (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL1604291 | 0.97 | FAAH (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL1604293 | 0.97 | FAAH (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL30517275 | 0.93 | G6PD (0.44) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL15237138 | 0.91 | CYP24A1 (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL7268342 | 0.91 | CYP24A1 (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL7268339 | 0.90 | CA12 (0.40) | CA12CA1CA9G6PDKEAP1 | |
| SCHEMBL7268345 | 0.90 | CA12 (0.40) | CA12CA1CA9G6PDKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545666-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-10 | — | — | US | disclosed |
| US-12473249-B2 | Aromatic compounds and pharmaceutical uses thereof | BASF AS (NO) | 2025-11-18 | — | — | US | disclosed |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
| US-20210380521-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | BASF AS (NO) | 2021-12-09 | — | — | US | disclosed |
| EP-3864001-A1 | ROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | BASF AS (NO) | 2021-08-18 | — | — | EP | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-02-07 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| WO-2013036866-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473249-B2 | Aromatic compounds and pharmaceutical uses thereof | GLS2, FFAR3, SLC10A1 | CA12 1054/4885CA1 1272/4885CA9 1011/4885 |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | CA12 2304/4885CA1 4584/4885CA9 3162/4885 |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | CA12 2304/4885CA1 4584/4885CA9 3162/4885 |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | CA12 2304/4885CA1 4584/4885CA9 3162/4885 |
| US-12545666-B2 | Itraconazole analogs and use thereof | SHH, SMO, GLI1 | CA12 132/4885CA1 2124/4885CA9 595/4885 |
| US-20210380521-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | GLS2, FFAR3, SLC10A1 | CA12 1054/4885CA1 1272/4885CA9 1011/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | CA12 2304/4885CA1 4584/4885CA9 3162/4885 |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | SHH, GLI1, KDR | CA12 2304/4885CA1 4584/4885CA9 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.