SCHEMBL14764823

SCHEMBL14764823

C=CCN(CC=C)[SiH](Cc1ccccc1)N(CC=C)CC=C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.36
GAA P10253 1/20 0.35
OPRM1 P35372 2/20 0.34
OPRD1 P41143 2/20 0.34
OPRK1 P41145 2/20 0.34
BCHE P06276 2/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
MAOB P27338 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CALM1 P0DP23 1/20 0.32
ESR1 P03372 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8761321 0.73 TSHR (0.42) GAA
SCHEMBL11101426 0.72 TP53 (0.44) OPRM1BCHEKDM4ECALM1
SCHEMBL5597920 0.71 CYP1A2 (0.38) CYP1A2SMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL2162787 0.69 CYP1A2 (0.37) CYP1A2OPRK1SMN1; SMN2KDM4EMEN1
SCHEMBL5968598 0.68 ALDH1A1 (0.37) GAAMAOBSMN1; SMN2CALM1
SCHEMBL2688603 0.68 BCHE (0.49) GAAOPRM1OPRD1OPRK1BCHE
SCHEMBL8658856 0.68 ALDH1A1 (0.37) GAAMAOBSMN1; SMN2CALM1
SCHEMBL516674 0.68 BCHE (0.49) GAAOPRM1OPRD1OPRK1BCHE
SCHEMBL1203909 0.67 TSHR (0.48) OPRK1MAOBCALM1
SCHEMBL5968611 0.67 MAOB (0.40) MAOBSMN1; SMN2CALM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2519548-B1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORP (JP) 2020-04-01 EP claimed
US-20190338052-A1 Processes For Preparing Aminosilane Functionalized Polymers BRIDGESTONE CORPORATION (JP) 2019-11-07 US claimed
US-20180155460-A1 Aminosilane Initiators And Functionalized Polymers Prepared Therefrom BRIDGESTONE CORPORATION (JP) 2018-06-07 US claimed
US-9884923-B2 Aminosilane initiators and functionalized polymers prepared therefrom BRIDGESTONE CORPORATION (JP) 2018-02-06 US claimed
US-20170283516-A1 PROCESSES FOR PREPARING AMINOSILANE FUNCTIONALIZED POLYMERS BRIDGESTONE CORPORATION (JP) 2017-10-05 US claimed
US-20130066008-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORPORATION (JP) 2013-03-14 US claimed
US-10745497-B2 Aminosilane initiators and functionalized polymers prepared therefrom BRIDGESTONE CORPORATION (JP) 2020-08-18 US disclosed
EP-2519548-B1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORP (JP) 2020-04-01 EP disclosed
US-20190338052-A1 Processes For Preparing Aminosilane Functionalized Polymers BRIDGESTONE CORPORATION (JP) 2019-11-07 US disclosed
US-10351636-B2 Processes for preparing aminosilane functionalized polymers BRIDGESTONE CORPORATION (JP) 2019-07-16 US disclosed
US-20180155460-A1 Aminosilane Initiators And Functionalized Polymers Prepared Therefrom BRIDGESTONE CORPORATION (JP) 2018-06-07 US disclosed
US-9884923-B2 Aminosilane initiators and functionalized polymers prepared therefrom BRIDGESTONE CORPORATION (JP) 2018-02-06 US disclosed
US-20170283516-A1 PROCESSES FOR PREPARING AMINOSILANE FUNCTIONALIZED POLYMERS BRIDGESTONE CORPORATION (JP) 2017-10-05 US disclosed
US-20160152756-A1 PROCESSES FOR PREPARING AMINOSILANE FUNCTIONALIZED POLYMERS BRIDGESTONE CORPORATION (JP) 2016-06-02 US disclosed
US-9255158-B2 Aminosilane initiators, functionalized polymers prepared therefrom and related processes BRIDGESTONE CORPORATION (JP) 2016-02-09 US disclosed
US-20150099852-A1 AMINOSILANE INITIATORS, FUNCTIONALIZED POLYMERS PREPARED THEREFROM AND RELATED PROCESSES BRIDGESTONE CORPORATION (JP) 2015-04-09 US disclosed
US-8916665-B2 Aminosilane initiators and functionalized polymers prepared therefrom BRIDGESTONE CORPORATION (JP) 2014-12-23 US disclosed
EP-2658727-B1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORP (JP) 2014-12-03 EP disclosed
US-20130281645-A1 Aminosilane Initiators And Functionalized Polymers Prepared Therefrom BRIDGESTONE CORPORATION (JP) 2013-10-24 US disclosed
US-20130066008-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORPORATION (JP) 2013-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10745497-B2 Aminosilane initiators and functionalized polymers prepared therefrom WEE1, WEE2, ITK CYP1A2 3373/4885GAA 4318/4885OPRM1 185/4885
US-20130066008-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM WEE1, WEE2, ITK CYP1A2 3373/4885GAA 4318/4885OPRM1 185/4885
US-20180155460-A1 Aminosilane Initiators And Functionalized Polymers Prepared Therefrom WEE1, WEE2, ITK CYP1A2 3373/4885GAA 4318/4885OPRM1 185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.