SCHEMBL2162787

SCHEMBL2162787

C=CCN(CC=C)[Si@@H](C)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.37
C5AR1 P21730 1/20 0.37
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TSHR P16473 1/20 0.33
RAB9A P51151 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
SLC6A2 P23975 1/20 0.33
HTR1D P28221 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR1E P28566 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5597920 0.81 CYP1A2 (0.38) CYP1A2C5AR1ALDH1A1LMNAHTT
SCHEMBL2268251 0.76 L3MBTL1 (0.35) ALDH1A1LMNAHTTTSHRHTR1A
SCHEMBL8761321 0.75 TSHR (0.42) ALDH1A1TSHRRAB9APYCR1
SCHEMBL10652512 0.72 TSHR (0.48) ALDH1A1LMNASMN1; SMN2TSHRRAB9A
SCHEMBL8992328 0.70 ALDH1A1 (0.33) ALDH1A1TSHR
SCHEMBL8760943 0.69 ESR1 (0.38) CYP1A2C5AR1ALDH1A1LMNAKDM4E
SCHEMBL14764823 0.69 CYP1A2 (0.36) CYP1A2KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL2153983 0.67 ALDH1A1 (0.35) ALDH1A1LMNAHTTMEN1KMT2A
SCHEMBL2267937 0.67 ALDH1A1 (0.35) ALDH1A1LMNAHTTMEN1KMT2A
SCHEMBL8770165 0.67 ALDH1A1 (0.33) ALDH1A1KDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2658727-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM Bridgestone Corporation (JP) 2013-11-06 EP claimed
EP-2519548-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM Bridgestone Corporation (JP) 2012-11-07 EP claimed
WO-2012091753-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORPORATION (JP) 2012-07-05 WO claimed
WO-2011082277-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORPORATION (JP) 2011-07-07 WO claimed
EP-2658727-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM Bridgestone Corporation (JP) 2013-11-06 EP disclosed
EP-2519548-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM Bridgestone Corporation (JP) 2012-11-07 EP disclosed
WO-2012091753-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORPORATION (JP) 2012-07-05 WO disclosed
WO-2011082277-A1 AMINOSILANE INITIATORS AND FUNCTIONALIZED POLYMERS PREPARED THEREFROM BRIDGESTONE CORPORATION (JP) 2011-07-07 WO disclosed