Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 14/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765127 | 0.77 | PDE2A (0.53) | PDE2APDE10AHTR2C | |
| SCHEMBL14354843 | 0.74 | POLB (0.54) | PDE2APDE10AHTR2CMEN1KMT2A | |
| SCHEMBL12502583 | 0.72 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL8022214 | 0.71 | LMNA (0.79) | GALR3NR2F2RAB9AMEN1LMNA | |
| SCHEMBL12502893 | 0.70 | PDE2A (1.00) | PDE2APDE10AMAOAMAOB | |
| SCHEMBL14054782 | 0.70 | PDE2A (0.67) | PDE2APDE10AMEN1KMT2A | |
| SCHEMBL7340895 | 0.70 | HTR2C (0.66) | HTR2CMEN1TP53MAPTKMT2A | |
| SCHEMBL14764776 | 0.69 | TYMS (0.70) | PDE2APDE10AMAOAMEN1KMT2A | |
| SCHEMBL13187013 | 0.69 | LMNA (0.85) | GALR3NR2F2RAB9AMEN1LMNA | |
| SCHEMBL14362116 | 0.68 | PDE2A (0.76) | PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |