Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.59 |
| ▸ | PIM1 | P11309 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455949 | 0.85 | ALDH1A1 (0.50) | KDM4EALDH1A1DYRK1ADYRK2PIM1 | |
| SCHEMBL32664904 | 0.83 | CDK2 (0.63) | KDM4EALDH1A1DYRK1ADYRK2PIM1 | |
| SCHEMBL15365749 | 0.83 | HSD17B10 (0.58) | KDM4EALDH1A1PIM1SMN1; SMN2LRRK2 | |
| SCHEMBL32664934 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1PIM1SMN1; SMN2NPSR1 | |
| SCHEMBL16456325 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1PIM1SMN1; SMN2 | |
| SCHEMBL14852007 | 0.80 | HPGD (0.53) | KDM4EALDH1A1PIM1SMN1; SMN2 | |
| SCHEMBL4784567 | 0.79 | BRD4 (0.65) | KDM4EALDH1A1DYRK1APIM1SMN1; SMN2 | |
| SCHEMBL12204663 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1DYRK1ADYRK2PIM1 | |
| SCHEMBL750158 | 0.77 | ALDH1A1 (1.00) | KDM4EALDH1A1DYRK1ADYRK2SMN1; SMN2 | |
| SCHEMBL24095114 | 0.76 | ALDH1A1 (0.51) | KDM4EALDH1A1DYRK1ADYRK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260022124-A1 | THERAPEUTIC COMPOUNDS AND METHODS | UNIV MINNESOTA (US) | 2026-01-22 | — | — | US | disclosed |
| EP-2753611-B1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-2753611-B1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2018-04-11 | — | — | EP | disclosed |
| US-20150246902-A1 | SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150246902-A1 | SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2015-09-03 | — | — | US | disclosed |
| WO-2013034048-A1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034048-A1 | SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260022124-A1 | THERAPEUTIC COMPOUNDS AND METHODS | NR5A1, CYP17A1, CNR1 | KDM4E 1972/4885ALDH1A1 663/4885DYRK1A 4505/4885 |
| US-20150246902-A1 | SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | EIF5B, EIF2AK2, HCCS | KDM4E 2423/4885ALDH1A1 158/4885DYRK1A 4854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.