Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 14/20 | 0.49 |
| ▸ | MMEL1 | Q495T6 | 5/20 | 0.48 |
| ▸ | ACE | P12821 | 4/20 | 0.47 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581319 | 0.89 | MMEL1 (0.59) | MMEMMEL1ACE | |
| SCHEMBL12975218 | 0.84 | MMEL1 (0.61) | MMEMMEL1ACEGPR34 | |
| SCHEMBL14765548 | 0.81 | MME (0.48) | MMEMMEL1ACEGPR34 | |
| SCHEMBL14873441 | 0.81 | MME (0.50) | MMEMMEL1ACEGPR34 | |
| SCHEMBL12975711 | 0.79 | MME (0.52) | MMEMMEL1ACEGPR34 | |
| SCHEMBL12974911 | 0.79 | MME (0.77) | MMEMMEL1 | |
| SCHEMBL8531544 | 0.79 | MME (0.65) | MMEMMEL1ACE | |
| SCHEMBL14952898 | 0.79 | MME (0.77) | MMEMMEL1 | |
| SCHEMBL15943083 | 0.77 | MMEL1 (0.50) | MMEMMEL1ACE | |
| SCHEMBL12974571 | 0.77 | MME (0.52) | MMEMMEL1ACEGPR34TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296240-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | COPPOLA GARY MARK (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296240-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | COPPOLA GARY MARK (US) | 2014-10-02 | — | — | US | disclosed |
| US-8394853-B2 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2013-03-12 | — | — | US | disclosed |
| US-8394853-B2 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2013-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296240-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | MME, AGTR1, REN | MME 1/4885MMEL1 299/4885ACE 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.