Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13265535 | 0.87 | ALDH1A1 (0.40) | ALDH1A1HSD17B10SMN1; SMN2TRPM5MAPK1 | |
| SCHEMBL10235035 | 0.87 | RAB9A (0.42) | ALDH1A1HSD17B10SMN1; SMN2NPSR1KDR | |
| SCHEMBL761133 | 0.82 | ALDH1A1 (0.45) | ALDH1A1HSD17B10SMN1; SMN2TRPM5MAPK1 | |
| SCHEMBL6090347 | 0.82 | ALDH1A1 (0.39) | ALDH1A1HSD17B10SMN1; SMN2TRPM5MAPK1 | |
| SCHEMBL24037602 | 0.81 | ALDH1A1 (0.38) | ALDH1A1HSD17B10SMN1; SMN2TRPM5MAPK1 | |
| SCHEMBL25768089 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HSD17B10SMN1; SMN2TRPM5MAPK1 | |
| SCHEMBL22142342 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HSD17B10SMN1; SMN2TRPM5MAPK1 | |
| SCHEMBL23075781 | 0.77 | FFAR1 (0.39) | ALDH1A1SMN1; SMN2MAPK1NPSR1RIPK2 | |
| SCHEMBL30375905 | 0.75 | NPC1 (0.47) | ALDH1A1HSD17B10NTRK1NTRK2ESR1 | |
| SCHEMBL1538312 | 0.75 | NPC1 (0.47) | ALDH1A1HSD17B10NTRK1NTRK2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569339-B2 | Soluble guanylate cyclase activators | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-29 | — | — | US | disclosed |
| US-20130065918-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065918-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | GUCY1A1, GUCY1A2, GUCY1B1 | ALDH1A1 1104/4885HSD17B10 2729/4885SMN1; SMN2 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.