Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.39 |
| ▸ | GABRP | O00591 | 6/20 | 0.39 |
| ▸ | GABRD | O14764 | 6/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.39 |
| ▸ | GABRE | P78334 | 6/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14770746 | 0.82 | KMO (0.38) | — | |
| SCHEMBL13472439 | 0.77 | MEN1 (0.39) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL10228362 | 0.74 | CYP1A2 (0.50) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL294157 | 0.72 | CYP1A2 (0.49) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL549184 | 0.71 | CYP1A2 (0.47) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL13472450 | 0.71 | ALDH1A1 (0.47) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11528320 | 0.69 | CYP1A2 (0.45) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL25276749 | 0.68 | CYP1A2 (0.44) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29537507 | 0.68 | CYP1A2 (0.44) | CYP1A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL19584584 | 0.68 | CYP1A2 (0.48) | CTSLCTSBCYP1A2GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920048-B2 | Substituted pyrimidines for inhibiting Raf kinase activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170158686-A1 | Compounds Useful as Raf Kinase Inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-06-08 | — | — | US | disclosed |
| US-9556177-B2 | Substituted 1,3-thiazoles as synthetic intermediates for preparation of Raf kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150080568-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | XOMA (US) LLC | 2015-03-19 | — | — | US | disclosed |
| US-8802657-B2 | Compounds useful as Raf kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-12 | — | — | US | disclosed |
| US-20130065858-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158686-A1 | Compounds Useful as Raf Kinase Inhibitors | BRAF, RAF1, ARAF | CTSL 4365/4885CTSB 3093/4885CYP1A2 4510/4885 |
| US-20130065858-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | CTSL 4365/4885CTSB 3093/4885CYP1A2 4510/4885 |
| US-20150080568-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | CTSL 4365/4885CTSB 3093/4885CYP1A2 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.