Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110907 | 0.79 | EGLN1 (0.60) | HDAC3NLRP3RIOK2P2RX7ALDH1A1 | |
| SCHEMBL15327088 | 0.76 | KDM1A (0.53) | P2RX7EGLN1 | |
| SCHEMBL14775742 | 0.74 | P2RX7 (0.50) | HDAC3P2RX7ALDH1A1KDM4EMAPT | |
| SCHEMBL2108506 | 0.73 | KDM4E (0.47) | NLRP3RIOK2P2RX7ALDH1A1EGLN1 | |
| SCHEMBL29373364 | 0.72 | MEN1 (0.61) | NLRP3ALDH1A1CSNK1DKDM4EMAPT | |
| SCHEMBL22246740 | 0.72 | P2RX7 (0.47) | NLRP3RIOK2P2RX7ALDH1A1CSNK1D | |
| SCHEMBL13675951 | 0.71 | MCHR1 (0.64) | TRPV1 | |
| SCHEMBL29099861 | 0.71 | MAPT (0.61) | HDAC3RIOK2ALDH1A1CSNK1DP2RY14 | |
| SCHEMBL3958875 | 0.68 | NPC1 (0.76) | ALDH1A1EGLN1TRPV1MAPTMEN1 | |
| SCHEMBL28158289 | 0.68 | MET (0.53) | ALDH1A1KDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |