Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30685737 | 0.78 | TDP1 (0.63) | P2RX7HDAC3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2111285 | 0.77 | EGLN1 (0.46) | P2RX7NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL1803010 | 0.76 | P2RX7 (0.78) | P2RX7NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL14775738 | 0.74 | HDAC3 (0.57) | P2RX7HDAC3NPC1RAB9AKDM4E | |
| SCHEMBL15327135 | 0.73 | NPC1 (0.72) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2109927 | 0.71 | ALOX12 (0.50) | P2RX7NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL27508818 | 0.69 | HPGD (0.63) | NPC1RAB9ASMN1; SMN2EPHX2KDM4E | |
| SCHEMBL1722042 | 0.68 | LMNA (0.50) | P2RX7NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL8797975 | 0.68 | EPHX2 (0.56) | P2RX7NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL7569274 | 0.67 | EPHX2 (0.51) | P2RX7NPC1RAB9ASMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |