Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MECP2 | P51608 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108832 | 0.86 | MEN1 (0.57) | SMN1; SMN2MAPTMEN1KMT2AEGLN1 | |
| SCHEMBL2110211 | 0.85 | EGLN1 (0.69) | SMN1; SMN2MAPTMEN1KMT2AEGLN1 | |
| SCHEMBL14775703 | 0.82 | KDR (0.72) | MAPTMEN1KMT2AEGLN1MMP2 | |
| SCHEMBL14775947 | 0.82 | EGLN1 (0.67) | SMN1; SMN2MAPTMEN1KMT2AEGLN1 | |
| SCHEMBL2110084 | 0.81 | MEN1 (0.55) | SMN1; SMN2MAPTMEN1KMT2AEGLN1 | |
| SCHEMBL8342736 | 0.80 | MMP2 (0.55) | SMN1; SMN2EGLN1MMP2TP53MAPK1 | |
| SCHEMBL2201326 | 0.79 | EGLN1 (1.00) | SMN1; SMN2MAPTMEN1KMT2AEGLN1 | |
| SCHEMBL2108838 | 0.79 | MAPT (0.60) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL2112798 | 0.76 | EGLN1 (0.53) | KMT2AEGLN1MMP2TP53ALDH1A1 | |
| SCHEMBL14775853 | 0.74 | EPHX1 (0.52) | SMN1; SMN2KMT2AEGLN1ALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |