Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.72 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260903 | 0.84 | KDR (1.00) | KDRHDAC6L3MBTL1TDP1GAA | |
| SCHEMBL29434873 | 0.84 | KDR (1.00) | KDRHDAC6L3MBTL1TDP1GAA | |
| SCHEMBL14775826 | 0.82 | SMN1; SMN2 (0.72) | EGLN1MMP2HDAC6L3MBTL1TDP1 | |
| SCHEMBL8342736 | 0.81 | MMP2 (0.55) | EGLN1MMP2L3MBTL1TDP1HTT | |
| SCHEMBL2108832 | 0.79 | MEN1 (0.57) | KDREGLN1MMP2L3MBTL1TDP1 | |
| SCHEMBL9755469 | 0.78 | KDR (0.65) | KDREGLN1SLC2A1HDAC6L3MBTL1 | |
| SCHEMBL2112798 | 0.78 | EGLN1 (0.53) | EGLN1SLC2A1MMP2L3MBTL1TDP1 | |
| SCHEMBL14775947 | 0.78 | EGLN1 (0.67) | EGLN1MMP2HDAC6ALDH1A1MEN1 | |
| SCHEMBL9400456 | 0.77 | NPC1 (0.68) | KDRTDP1GAAALDH1A1MEN1 | |
| SCHEMBL28434027 | 0.77 | KDR (0.63) | KDRMMP2HDAC6L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |