Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MECP2 | P51608 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775826 | 0.86 | SMN1; SMN2 (0.72) | MEN1KMT2AMAPTSMN1; SMN2CASP3 | |
| SCHEMBL2110084 | 0.83 | MEN1 (0.55) | MEN1KMT2AMAPTSMN1; SMN2CASP3 | |
| SCHEMBL2108838 | 0.81 | MAPT (0.60) | MEN1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL8342736 | 0.80 | MMP2 (0.55) | SMN1; SMN2MMP2TDP1POLBEGLN1 | |
| SCHEMBL14775947 | 0.79 | EGLN1 (0.67) | MEN1KMT2AMAPTSMN1; SMN2MMP2 | |
| SCHEMBL14775703 | 0.79 | KDR (0.72) | MEN1KMT2AMAPTMMP2TDP1 | |
| SCHEMBL2110211 | 0.77 | EGLN1 (0.69) | MEN1KMT2AMAPTSMN1; SMN2EGLN1 | |
| SCHEMBL9400389 | 0.74 | NPC1 (0.66) | MEN1KMT2AMAPTSMN1; SMN2MMP2 | |
| SCHEMBL2112798 | 0.74 | EGLN1 (0.53) | KMT2AMMP2TDP1POLBEGLN1 | |
| SCHEMBL14775853 | 0.74 | EPHX1 (0.52) | KMT2ASMN1; SMN2TDP1POLBEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | claimed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | disclosed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | disclosed |
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | disclosed |
| WO-2007068316-A1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MKI67, CCNT1, CCNY | MEN1 746/4885KMT2A 1109/4885MAPT 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.