Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | EP300 | Q09472 | 1/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545906 | 0.86 | HDAC1 (0.77) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14775853 | 0.83 | EPHX1 (0.52) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9755456 | 0.81 | DEGS1 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28601651 | 0.81 | HTT (0.76) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15923232 | 0.80 | HDAC1 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18788282 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18788303 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15444290 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18788301 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4897111 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |