Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963047 | 0.88 | HPGD (0.35) | HPGDMAPK1THRBHCRTR1HCRTR2 | |
| SCHEMBL1060720 | 0.86 | HPGD (0.34) | HPGDMAPK1THRBHCRTR1HCRTR2 | |
| SCHEMBL14780908 | 0.81 | HPGD (0.34) | HPGD | |
| SCHEMBL1063037 | 0.77 | HPGD (0.35) | HPGDMAPK1TP53L3MBTL1KMT2A | |
| SCHEMBL12962809 | 0.73 | HPGD (0.36) | HPGDMAPK1THRBL3MBTL1HDAC4 | |
| SCHEMBL1061205 | 0.71 | HPGD (0.35) | HPGDMAPK1L3MBTL1 | |
| SCHEMBL1062426 | 0.69 | LMNA (0.39) | HPGDMAPK1TP53L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL1061654 | 0.69 | LMNA (0.39) | MAPK1L3MBTL1MEN1KMT2AADORA2A | |
| SCHEMBL1062229 | 0.67 | HPGD (0.35) | HPGD | |
| SCHEMBL1062649 | 0.65 | ALDH1A1 (0.40) | HPGDMAPK1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399449-B2 | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-03-19 | — | — | US | disclosed |