Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061448 | 0.86 | L3MBTL1 (0.65) | FEN1MEN1KMT2AP2RX4KDM4E | |
| SCHEMBL1063193 | 0.81 | FEN1 (0.51) | FEN1MEN1KMT2AP2RX4KDM4E | |
| SCHEMBL14780923 | 0.78 | ALDH1A1 (0.70) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL28312049 | 0.77 | P2RX4 (0.57) | FEN1MEN1KMT2AP2RX4KDM4E | |
| SCHEMBL6086588 | 0.76 | ALDH1A1 (0.59) | FEN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12932651 | 0.76 | L3MBTL1 (0.69) | MEN1KMT2AP2RX4KDM4ETP53 | |
| SCHEMBL1522936 | 0.76 | KDM4E (0.81) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL18582662 | 0.76 | L3MBTL1 (0.71) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL6087197 | 0.76 | ALDH1A1 (0.73) | FEN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2206316 | 0.75 | KMT2A (0.56) | FEN1MEN1KMT2AP2RX4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399449-B2 | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-03-19 | — | — | US | disclosed |