Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457160 | 0.98 | SLC22A2 (0.37) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL3285298 | 0.90 | EPHX2 (0.36) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL3282755 | 0.90 | EPHX2 (0.36) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL23111395 | 0.85 | SLC22A2 (0.39) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL30538966 | 0.84 | EPHX2 (0.44) | EPHX2NPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL16908469 | 0.76 | EPHX2 (0.33) | EPHX2ALDH1A1 | |
| SCHEMBL2927660 | 0.75 | SLC22A2 (0.42) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL6346242 | 0.71 | SLC22A2 (0.39) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL9282423 | 0.71 | SLC22A2 (0.39) | SLC22A2SLC47A1MAPTEPHX2NPC1 | |
| SCHEMBL1324024 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036713-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | EVONIK DEGUSSA GMBH (DE) | 2009-02-05 | — | — | US | claimed |
| EP-1991520-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | Evonik Degussa GmbH (DE) | 2008-11-19 | — | — | EP | claimed |
| WO-2007101769-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | EVONIK DEGUSSA GMBH (DE) | 2007-09-13 | — | — | WO | claimed |
| US-20070213540-A1 | Process for the hydrogenation of imines | DEGUSSA AG (DE) | 2007-09-13 | — | — | US | claimed |
| US-20110077418-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | CHEMINOVA A/S (DK) | 2011-03-31 | — | — | US | disclosed |
| WO-2010094164-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | CHEMINOVA A/S (DK) | 2010-08-26 | — | — | WO | disclosed |
| US-20090036713-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | EVONIK DEGUSSA GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| EP-1991520-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | Evonik Degussa GmbH (DE) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007101769-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | EVONIK DEGUSSA GMBH (DE) | 2007-09-13 | — | — | WO | disclosed |
| US-20070213540-A1 | Process for the hydrogenation of imines | DEGUSSA AG (DE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077418-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | INTS9, INTS6, INF2 | SLC22A2 3737/4885SLC47A1 3921/4885MAPT 4711/4885 |
| US-20090036713-A1 | PROCESS FOR THE HYDROGENATION OF IMINES | IPO5, IPO4, HRH3 | SLC22A2 2802/4885SLC47A1 3430/4885MAPT 3876/4885 |
| US-20070213540-A1 | Process for the hydrogenation of imines | KCNH3, KCNH2, KMO | SLC22A2 2216/4885SLC47A1 4167/4885MAPT 4063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.