Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13833795 | 0.84 | MAPT (0.55) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL13833651 | 0.82 | POLB (0.53) | KDM4EPKMAPOBEC3AAPOBEC3GMAPT | |
| Trifluoromethanesulfonic Acid SCHEMBL14777194 | 0.75 | UHRF1 (0.47) | KDM4EPKMAPOBEC3AAPOBEC3GMAPT | |
| SCHEMBL13833700 | 0.71 | MAPT (0.55) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL14777503 | 0.69 | POLB (0.55) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL13833712 | 0.69 | LMNA (0.55) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL13833660 | 0.68 | MAPT (0.66) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL13833836 | 0.68 | POLB (0.53) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL13833847 | 0.67 | ADORA1 (0.51) | KDM4EMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL14788083 | 0.66 | APEX1 (0.49) | KDM4EMAPTPOLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072473-A1 | COMPOUNDS FOR TREATING PROTEIN FOLDING DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. | 2013-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072473-A1 | COMPOUNDS FOR TREATING PROTEIN FOLDING DISORDERS | HSPA5, PSMG3, VCP | KDM4E 3155/4885PKM 1635/4885APOBEC3A 3511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.