Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.33 |
| ▸ | LMNA | P02545 | 7/20 | 0.33 |
| ▸ | HTT | P42858 | 7/20 | 0.33 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24701731 | 0.95 | RAB9A (0.36) | RAB9ALMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL19531765 | 0.79 | ALDH1A1 (0.30) | RAB9ALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24701896 | 0.77 | ALOX5 (0.32) | RAB9ALMNAHTTSMN1; SMN2ALOX5 | |
| SCHEMBL20674610 | 0.76 | CYP1A2 (0.35) | KDM4EALDH1A1ALOX5PTGS1PTGS2 | |
| SCHEMBL23937907 | 0.74 | ALOX5 (0.33) | RAB9ANPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL20674619 | 0.74 | CA12 (0.36) | LMNAKDM4EALDH1A1RXFP1HTR6 | |
| SCHEMBL19844861 | 0.74 | POLB (0.32) | RAB9ALMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL20674613 | 0.73 | CYP1A2 (0.31) | RAB9ALMNAHTTSMN1; SMN2ALOX5 | |
| SCHEMBL23937908 | 0.73 | ALOX5 (0.35) | KDM4EALOX5PTGS1PTGS2CHRM2 | |
| SCHEMBL18164146 | 0.73 | RXFP1 (0.39) | RAB9ALMNAHTTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170312292-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | WUXI APPTEC (SHANGHAI) CO. LTD (CN) | 2017-11-02 | — | — | US | disclosed |
| US-9365574-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20130072492-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME LLC | 2013-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072492-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | GUCY1A2, GUCY1A1, PDE2A | RAB9A 456/4885LMNA 1367/4885HTT 3264/4885 |
| US-20170312292-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, CREBBP, HDAC1 | RAB9A 4381/4885LMNA 2049/4885HTT 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.