⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783222 | 0.83 | — | — | |
| SCHEMBL12951345 | 0.81 | LMNA (0.31) | — | |
| SCHEMBL20783127 | 0.79 | LMNA (0.35) | — | |
| SCHEMBL27684403 | 0.78 | TSHR (0.30) | — | |
| SCHEMBL23501501 | 0.77 | ALOX15 (0.40) | — | |
| SCHEMBL25960852 | 0.77 | — | — | |
| SCHEMBL16837161 | 0.77 | — | — | |
| SCHEMBL4957158 | 0.77 | LMNA (0.34) | — | |
| SCHEMBL1158850 | 0.76 | — | — | |
| SCHEMBL8290885 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928868-B1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN LA ROCHE (CH) | 2017-08-09 | — | — | EP | claimed |
| EP-2928882-B1 | PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2017-01-18 | — | — | EP | claimed |
| US-9512141-B2 | Pyrazine derivatives as CB2 receptor agonists | HOFFMANN-LA ROCHE INC. (US) | 2016-12-06 | — | — | US | claimed |
| US-9303012-B2 | Pyridine-2-amides useful as CB2 agonists | HOFFMAN-LA ROCHE INC. (US) | 2016-04-05 | — | — | US | claimed |
| US-20150299165-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-22 | — | — | US | claimed |
| US-20150299220-A1 | NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-22 | — | — | US | claimed |
| EP-2928882-A1 | NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-10-14 | — | — | EP | claimed |
| WO-2014086807-A1 | NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | claimed |
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | claimed |
| CN-118511230-A | Method for producing sulfide solid electrolyte | 出光兴产株式会社 | 2024-08-16 | — | — | CN | disclosed |
| CN-118475993-A | Method for producing sulfide solid electrolyte | 出光兴产株式会社 | 2024-08-09 | — | — | CN | disclosed |
| WO-2024108198-A2 | METHODS OF TREATING OBESITY WITH AN MC4R AGONIST | RHYTHM PHARMACEUTICALS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| CN-117999515-A | Photosensitive composition, cured product, display device, electronic component, and method for producing cured product | 东丽株式会社 | 2024-05-07 | — | — | CN | disclosed |
| CN-117716448-A | Sulfide solid electrolyte | 出光兴产株式会社 | 2024-03-15 | — | — | CN | disclosed |
| US-20150299165-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-22 | — | — | US | disclosed |
| EP-2928882-A1 | NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-10-14 | — | — | EP | disclosed |
| WO-2014086807-A1 | NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | disclosed |
| US-20140155376-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2014-06-05 | — | — | US | disclosed |
| EP-2703456-A2 | Yellow ink composition for inkjet recording, and inkjet recording method and inkjet recorded material | Ricoh Company, Ltd. (JP) | 2014-03-05 | — | — | EP | disclosed |
| CN-102177133-A | Tetrahydronaphthalene compounds | ACTELION PHARMACEUTICALS LTD | 2011-09-07 | — | — | CN | disclosed |