Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PTAFR | P25105 | 4/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 4/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4662136 | 0.87 | RAB9A (0.83) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL3204774 | 0.86 | LMNA (0.67) | KMT2AMEN1MAPTGAANAMPT | |
| SCHEMBL13211915 | 0.83 | RAB9A (0.70) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL506616 | 0.82 | NAMPT (0.67) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL13766380 | 0.82 | HDAC2 (0.63) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL2118595 | 0.82 | HDAC2 (0.69) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL13762095 | 0.81 | ALDH1A1 (0.76) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL1831475 | 0.81 | HDAC2 (0.62) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL19226497 | 0.80 | LMNA (0.64) | HDAC2HDAC8HDAC6RAB9AKMT2A | |
| SCHEMBL8739011 | 0.79 | RAB9A (0.66) | HDAC2HDAC8HDAC6RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758380-B1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | HOFFMANN LA ROCHE (CH) | 2015-10-21 | — | — | EP | disclosed |
| US-9073881-B2 | Benzoic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2758380-A1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013041468-A1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-28 | — | — | WO | disclosed |
| US-20130079346-A1 | BENZOIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079346-A1 | BENZOIC ACID DERIVATIVES | EIF4EBP1, EIF4E, EIF4A2 | HDAC2 215/4885HDAC8 408/4885HDAC6 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.