SCHEMBL14798043

SCHEMBL14798043

CCCOc1nc(Sc2nccs2)nc2oc(-c3cc(C)c(OCC(=O)O)c(C)c3)nc12

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 0.38
PPARG P37231 1/20 0.32
PPARD Q03181 1/20 0.32
CTSA P10619 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2147337 0.89 S1PR1 (0.39) S1PR1PPARGPPARD
SCHEMBL15021688 0.85 S1PR1 (0.43) S1PR1PPARGPPARD
SCHEMBL2146380 0.84 S1PR1 (0.40) S1PR1PPARGPPARD
SCHEMBL14796973 0.82 S1PR1 (0.52) S1PR1CTSA
SCHEMBL2146693 0.81 S1PR1 (0.48) S1PR1PPARGPPARD
SCHEMBL2146740 0.80 S1PR1 (0.47) S1PR1PPARGPPARD
SCHEMBL2226382 0.79 DCUN1D1 (0.39) CTSA
SCHEMBL15021666 0.78 S1PR1 (0.42) S1PR1PPARGPPARD
SCHEMBL14798730 0.78 S1PR1 (0.36) S1PR1PPARGPPARD
SCHEMBL14798762 0.77 S1PR1 (0.44) S1PR1PPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748436-B2 Carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring SANOFI (FR) 2014-06-10 US disclosed
US-20130079357-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2013-03-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130079357-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING DPYD, OXGR1, ALDH1A1 S1PR1 2137/4885PPARG 573/4885PPARD 878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.