Sugi Predict

Sugi Predict / Compounds / SCHEMBL2226382

SCHEMBL2226382

SCHEMBL2226382

CCCOc1nc(Sc2nccs2)nc2oc(-c3cccc(C)c3)nc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DCUN1D1 Q96GG9 3/20 0.39
▸ MAPT P10636 5/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ RAB9A P51151 5/20 0.33
▸ ALDH1A1 P00352 4/20 0.33
▸ KDM4E B2RXH2 4/20 0.33
▸ HPGD P15428 4/20 0.33
▸ SMN1; SMN2 Q16637 4/20 0.33
▸ HSD17B10 Q99714 3/20 0.33
▸ TSHR P16473 2/20 0.33
▸ TP53 P04637 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ CASP3 P42574 1/20 0.33
▸ SENP8 Q96LD8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1828532 0.83 MAPT (0.38) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL14798043 0.79 S1PR1 (0.38) CTSA
SCHEMBL14974284 0.76 MAPT (0.42) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL1828489 0.75 SDHB (0.39) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL1831253 0.72 MAPT (0.39) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL2224679 0.72 RAB9A (0.36) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL1828263 0.72 RAB9A (0.39) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL1829407 0.72 MAPT (0.38) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL2225576 0.71 RAB9A (0.39) MAPTMEN1KMT2ARAB9AALDH1A1
SCHEMBL1830757 0.70 PBRM1 (0.36) MAPTMEN1KMT2ARAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785439-B2 2,5,7-substituted oxazolopyrimidine derivatives SANOFI (FR) 2014-07-22 — — US disclosed
US-8785439-B2 2,5,7-substituted oxazolopyrimidine derivatives SANOFI (FR) 2014-07-22 — — US disclosed
US-8785439-B2 2,5,7-substituted oxazolopyrimidine derivatives SANOFI (FR) 2014-07-22 — — US disclosed
EP-2523961-B1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI SA (FR) 2013-12-18 — — EP disclosed
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2013-05-30 — — US disclosed
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2013-05-30 — — US disclosed
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2013-05-30 — — US disclosed
EP-2523961-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2012-11-21 — — EP disclosed
WO-2011086075-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI-AVENTIS (FR) 2011-07-21 — — WO disclosed
WO-2011086075-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI-AVENTIS (FR) 2011-07-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES DPYD, UNG, CDK2 DCUN1D1 1991/4885MAPT 4602/4885MEN1 3792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.