Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14802148 | 0.84 | PRKDC (0.41) | PRKDCMEN1KMT2AMAPTLMNA | |
| SCHEMBL14802143 | 0.81 | PRKDC (0.52) | PRKDCMEN1KMT2AMAPTPIK3CD | |
| SCHEMBL14447676 | 0.79 | PRKDC (0.37) | PRKDCMAPTPIK3CDPIK3CB | |
| SCHEMBL14468581 | 0.74 | PRKDC (0.38) | PRKDCMAPTP2RY12 | |
| SCHEMBL14802150 | 0.74 | PRKDC (0.48) | PRKDCMAPTKDM4EGAAHPGD | |
| SCHEMBL14447675 | 0.73 | PRKDC (0.49) | PRKDCMAPTKDM4EGAAHPGD | |
| SCHEMBL14802155 | 0.73 | MAOA (0.49) | PRKDC | |
| SCHEMBL5451016 | 0.72 | PRKDC (0.41) | PRKDCMEN1KMT2AP2RY12 | |
| SCHEMBL14802154 | 0.71 | PRKDC (0.46) | PRKDCP2RY12 | |
| SCHEMBL1938064 | 0.70 | SLC16A3 (0.51) | PRKDCMEN1KMT2AMAPTPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |