Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14802147 | 0.84 | PRKDC (0.40) | PRKDCMEN1KMT2AP2RY12PIK3CD | |
| SCHEMBL14802143 | 0.81 | PRKDC (0.52) | PRKDCMEN1KMT2APIK3CDPIK3CA | |
| SCHEMBL14447676 | 0.73 | PRKDC (0.37) | PRKDCPIK3CDPIK3CBMAPT | |
| SCHEMBL1938064 | 0.71 | SLC16A3 (0.51) | PRKDCMEN1KMT2APIK3CDPIK3CA | |
| SCHEMBL14802149 | 0.71 | KDM4E (0.47) | PRKDCMEN1KMT2AMAPTLMNA | |
| SCHEMBL14802157 | 0.71 | PRKDC (0.50) | PRKDCMEN1KMT2AMAPTKDM4E | |
| SCHEMBL5444190 | 0.70 | PRKDC (0.56) | PRKDCMAPTGAA | |
| SCHEMBL5440694 | 0.70 | PRKDC (0.55) | PRKDCMEN1KMT2AMAPTKDM4E | |
| SCHEMBL5781920 | 0.69 | PRKDC (0.53) | PRKDCPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL5441394 | 0.69 | PRKDC (0.50) | PRKDCPIK3CDPIK3CAPIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |