Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | MMP2 | P08253 | 2/20 | 0.71 |
| ▸ | MMP8 | P22894 | 2/20 | 0.71 |
| ▸ | BACE1 | P56817 | 6/20 | 0.55 |
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TOP2A | P11388 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12599489 | 1.00 | MMP9 (0.71) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL13663908 | 0.92 | MMP9 (0.76) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL15298278 | 0.88 | MMP9 (0.64) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL12402527 | 0.87 | BACE1 (0.72) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL12402525 | 0.87 | MMP9 (0.69) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL4005087 | 0.84 | IAPP (0.71) | MMP9NFKB1MMP2BACE1APP | |
| SCHEMBL4005096 | 0.84 | IAPP (0.71) | MMP9NFKB1MMP2BACE1APP | |
| SCHEMBL12593153 | 0.84 | IAPP (0.67) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL12565705 | 0.83 | MMP9 (1.00) | MMP9NFKB1MMP2MMP8BACE1 | |
| SCHEMBL10077702 | 0.83 | MMP9 (1.00) | MMP9NFKB1MMP2MMP8BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404651-B2 | Compositions and methods for treating viral infections | SPRING BANK PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |