Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.55 |
| ▸ | WNT1 | P04628 | 12/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.54 |
| ▸ | CLK2 | P49760 | 11/20 | 0.53 |
| ▸ | CLK3 | P49761 | 10/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.51 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14792911 | 0.93 | DYRK1A (0.55) | DYRK1AWNT1CLK2CLK3CDK2 | |
| SCHEMBL14792131 | 0.89 | DYRK1A (0.67) | DYRK1AWNT1CSNK2A1CLK2CLK3 | |
| SCHEMBL14804599 | 0.88 | DYRK1A (0.67) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL14804382 | 0.88 | DYRK1A (0.52) | DYRK1AWNT1CSNK2A1CLK2CLK3 | |
| SCHEMBL14803969 | 0.88 | DYRK1A (0.62) | DYRK1AWNT1CSNK2A1CLK2CLK3 | |
| SCHEMBL14804428 | 0.87 | DYRK1A (0.65) | DYRK1AWNT1CSNK2A1CLK2CLK3 | |
| SCHEMBL14804376 | 0.87 | DYRK1A (0.67) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL14792633 | 0.86 | DYRK1A (0.57) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL14804373 | 0.86 | CSNK2A1 (0.59) | DYRK1AWNT1CSNK2A1CLK2CLK3 | |
| SCHEMBL14804375 | 0.86 | DYRK1A (0.74) | DYRK1AWNT1CSNK2A1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130079329-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/Beta-CATENIN SIGNALING PATHWAY INHIBITORS | VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079329-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/Beta-CATENIN SIGNALING PATHWAY INHIBITORS | WNT3, WNT1, WNT3A | DYRK1A 733/4885WNT1 2/4885CSNK2A1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.