Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.94 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.64 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 5/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10211959 | 0.97 | DHODH (1.00) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL5071964 | 0.89 | DHODH (0.76) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL18038275 | 0.88 | DHODH (0.79) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL5333968 | 0.88 | DHODH (0.79) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL5073318 | 0.87 | DHODH (0.82) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL14836765 | 0.86 | DHODH (0.71) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL9091153 | 0.84 | DHODH (0.73) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL1419869 | 0.84 | DHODH (0.73) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL8867127 | 0.84 | DHODH (0.73) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E | |
| SCHEMBL12753158 | 0.84 | DHODH (0.69) | DHODHALDH1A3ALDH1A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210128552-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2021-05-06 | — | — | US | disclosed |
| US-20190142826-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-05-16 | — | — | US | disclosed |
| US-10058549-B2 | Imidazo[1,2-α]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2018-08-28 | — | — | US | disclosed |
| US-20170151236-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2017-06-01 | — | — | US | disclosed |
| EP-2190844-B3 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2013-07-17 | — | — | EP | disclosed |
| EP-2190844-B1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2013-04-10 | — | — | EP | disclosed |
| US-8404707-B2 | Imidazo [1, 2-a] pyrrolo [3, 2-c] pyridine compounds useful as pestivirus inhibitors | UNIVERSITE D'AUVERGNE CLERMONT 1 (FR) | 2013-03-26 | — | — | US | disclosed |
| US-20110077248-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. | 2011-03-31 | — | — | US | disclosed |
| US-20100093781-A1 | IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | UNIVERSITE D'AUVERGNE CLERMONT 1 (FR) | 2010-04-15 | — | — | US | disclosed |
| EP-2125807-A2 | IMIDAZO[1,2-A]PYRROLO[3,2-C]PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | Katholieke Universiteit Leuven (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008070937-A2 | IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2008-06-19 | — | — | WO | disclosed |
| EP-1257551-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2007-09-05 | — | — | EP | disclosed |
| US-7041675-B2 | Heterocyclic compounds and their use as PARP inhibitors | ABBOTT GMBH & CO. KG (DE) | 2006-05-09 | — | — | US | disclosed |
| US-20030134843-A1 | Heterocyclic compounds and their use as parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-07-17 | — | — | US | disclosed |
| US-5498774-A | FUNGICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0404190-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-10-25 | — | — | EP | disclosed |
| EP-0404190-A1 | Condensed heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170151236-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR2A, HTR1A, HTR2B | DHODH 3446/4885ALDH1A3 3444/4885ALDH1A2 1534/4885 |
| US-10058549-B2 | Imidazo[1,2-α]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | HTR1A, HTR2A, HTR5A | DHODH 3148/4885ALDH1A3 2465/4885ALDH1A2 1070/4885 |
| US-20110077248-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT3, SIRT1, SIRT2 | DHODH 1141/4885ALDH1A3 2233/4885ALDH1A2 1871/4885 |
| US-20030134843-A1 | Heterocyclic compounds and their use as parp inhibitors | PARP1, PARP2, PARP11 | DHODH 1990/4885ALDH1A3 2928/4885ALDH1A2 2661/4885 |
| US-20210128552-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR1A, HTR2A, HTR2B | DHODH 3514/4885ALDH1A3 3342/4885ALDH1A2 1544/4885 |
| US-20190142826-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR1A, HTR2A, HTR5A | DHODH 3223/4885ALDH1A3 2484/4885ALDH1A2 1073/4885 |
| US-20100093781-A1 | IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | PPM1D, CDKN1A, PPM1A | DHODH 497/4885ALDH1A3 3587/4885ALDH1A2 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.