Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14814647 | 0.80 | RAB9A (0.46) | RAB9AUSP2MAPK14ALDH1A1KDM4E | |
| SCHEMBL14826094 | 0.78 | SRC (0.32) | KIF11MAPT | |
| SCHEMBL14814684 | 0.77 | CREBBP (0.41) | — | |
| SCHEMBL11684104 | 0.76 | USP2 (0.70) | RAB9AUSP2ALDH1A1KDM4EGCGR | |
| SCHEMBL14814468 | 0.75 | RAB9A (0.44) | RAB9AUSP2MAPK14KDM4ELMNA | |
| SCHEMBL14814302 | 0.75 | MAPT (0.48) | RAB9AUSP2MAPK14KDM4ELMNA | |
| SCHEMBL9205598 | 0.75 | USP2 (0.58) | RAB9AUSP2MAPK14MAPK13MAPK12 | |
| SCHEMBL14814305 | 0.73 | RAB9A (0.49) | RAB9AUSP2MAPK14ALDH1A1KDM4E | |
| SCHEMBL14814451 | 0.70 | USP2 (0.47) | RAB9AUSP2MAPK14MAPK13MAPK12 | |
| SCHEMBL14814649 | 0.69 | RAB9A (0.48) | RAB9AUSP2LMNAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809372-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2014-08-19 | — | — | US | claimed |
| EP-2760833-A1 | PYRIDINE DERIVATIVES | Endo Pharmaceuticals Inc. (US) | 2014-08-06 | — | — | EP | claimed |
| US-20130085148-A1 | Pyridine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | US | claimed |
| WO-2013049559-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | WO | claimed |
| US-20170073339-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20170073339-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20170073339-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-9533981-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2017-01-03 | — | — | US | disclosed |
| US-9533981-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160340310-A9 | Pyridine Derivatives | ENDO PHARMACEUTICALS, INC. | 2016-11-24 | — | — | US | disclosed |
| US-20160340310-A9 | Pyridine Derivatives | ENDO PHARMACEUTICALS, INC. | 2016-11-24 | — | — | US | disclosed |
| US-20160340310-A9 | Pyridine Derivatives | ENDO PHARMACEUTICALS, INC. | 2016-11-24 | — | — | US | disclosed |
| US-20140235652-A1 | Pyridine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-8809372-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809372-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809372-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130085148-A1 | Pyridine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085148-A1 | Pyridine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085148-A1 | Pyridine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | US | disclosed |
| WO-2013049559-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085148-A1 | Pyridine Derivatives | CYP2A7, CYP21A2, CYP3A7 | RAB9A 3164/4885USP2 1959/4885MAPK14 1449/4885 |
| US-20170073339-A1 | PYRIDINE DERIVATIVES | CYP21A2, CYP26A1, CYP11B1 | RAB9A 3120/4885USP2 2767/4885MAPK14 1036/4885 |
| US-20160340310-A9 | Pyridine Derivatives | CYP2A7, CYP21A2, CYP3A7 | RAB9A 3164/4885USP2 1959/4885MAPK14 1449/4885 |
| US-20140235652-A1 | Pyridine Derivatives | CYP2A7, CYP21A2, CYP3A7 | RAB9A 3164/4885USP2 1959/4885MAPK14 1449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.