Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14827149 | 0.92 | KMT2A (0.55) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| SCHEMBL14814557 | 0.87 | DHODH (0.63) | NPSR1ALDH1A1KMT2ADHODHMEN1 | |
| SCHEMBL14814999 | 0.82 | MEN1 (0.51) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| SCHEMBL1539910 | 0.80 | KMT2A (0.47) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| SCHEMBL14814993 | 0.79 | DHODH (0.47) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL1539902 | 0.79 | KMT2A (0.46) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| SCHEMBL14833280 | 0.76 | DHODH (0.45) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| SCHEMBL14814909 | 0.76 | MAPT (0.51) | SMN1; SMN2LMNAMAPTALDH1A1KMT2A | |
| SCHEMBL15064944 | 0.72 | KMT2A (0.70) | SMN1; SMN2NPSR1LMNAHTTMAPT | |
| SCHEMBL15948911 | 0.71 | ALDH1A1 (0.56) | SMN1; SMN2NPSR1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049585-A1 | ARYLSUBSTITUTED THIAZOLOTRIAZOLES AND THIAZOLOIMIDAZOLES | HENGRUI (USA), LTD. (US) | 2013-04-04 | — | — | WO | disclosed |
| US-20130085157-A1 | ARYLSUBSTITUTED THIAZOLOTRIAZOLES AND THIAZOLOIMIDAZOLES | SMITH EMILIE D (US) | 2013-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085157-A1 | ARYLSUBSTITUTED THIAZOLOTRIAZOLES AND THIAZOLOIMIDAZOLES | TGM2, CCT5, TSHR | SMN1; SMN2 2309/4885NPSR1 2759/4885LMNA 4530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.