Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 3/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13113114 | 0.86 | ALDH1A1 (0.38) | HTR1AHTR2AHTR7HTR6PABPC1 | |
| SCHEMBL13872273 | 0.86 | METAP1 (0.35) | PABPC1ALOX15MAPK1ALDH1A1MEN1 | |
| SCHEMBL13872222 | 0.86 | KDM4E (0.31) | ALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL13871869 | 0.84 | HTR2C (0.34) | HTR2APABPC1ALOX15MAPK1ALDH1A1 | |
| SCHEMBL13871978 | 0.83 | PRKCI (0.38) | HTR1AHTR2AHTR7HTR6ALDH1A1 | |
| SCHEMBL13871937 | 0.82 | MEN1 (0.36) | HTR6PABPC1ALOX15MAPK1ALDH1A1 | |
| SCHEMBL13871905 | 0.82 | MEN1 (0.39) | PABPC1ALOX15MAPK1ALDH1A1MEN1 | |
| SCHEMBL13871950 | 0.80 | MEN1 (0.38) | PABPC1ALOX15MAPK1ALDH1A1MEN1 | |
| SCHEMBL13872259 | 0.79 | MEN1 (0.39) | PABPC1ALOX15MAPK1ALDH1A1MEN1 | |
| SCHEMBL13871966 | 0.78 | MEN1 (0.40) | HTR2AHTR6PABPC1ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2573080-A1 | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses | The United States of America, as Represented by the Secretary, Department of Health and Human Services (US) | 2013-03-27 | — | — | EP | disclosed |