Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13113728 | 0.86 | ALDH1A1 (0.39) | PRKCIKDM1ACYP2A6HTR6HTR1A | |
| SCHEMBL13872293 | 0.85 | HTR6 (0.31) | HTR6 | |
| SCHEMBL13872269 | 0.84 | PRKCI (0.40) | PRKCICYP2A6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13872217 | 0.83 | PRKCI (0.39) | PRKCICYP2A6HTR2ASLC6A2SLC6A4 | |
| SCHEMBL13871842 | 0.83 | PRKCI (0.39) | PRKCICYP2A6HTR2AHTR7SLC6A2 | |
| SCHEMBL13871952 | 0.83 | PRKCI (0.39) | PRKCICYP2A6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14818556 | 0.83 | HTR1A (0.32) | HTR6HTR1AHTR2AHTR7ALDH1A1 | |
| SCHEMBL13872131 | 0.82 | PRKCI (0.42) | PRKCICYP2A6HTR6SLC6A2SLC6A4 | |
| SCHEMBL13872134 | 0.81 | PRKCI (0.38) | PRKCICYP2A6HTR7SLC6A2SLC6A4 | |
| SCHEMBL14818629 | 0.81 | PRKCI (0.38) | PRKCICYP2A6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |