Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.51 |
| ▸ | HNF4A | P41235 | 2/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
| ▸ | ACLY | P53396 | 3/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.46 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27918808 | 0.88 | ACMSD (0.63) | ACMSDHNF4AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL1483201 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2ACMSDHNF4AAKR1C4 | |
| SCHEMBL8376377 | 0.81 | ACMSD (0.50) | ACMSDHNF4AAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL840276 | 0.78 | AKR1C3 (0.51) | SMN1; SMN2AKR1C4AKR1C3AKR1C2AKR1C1 | |
| Acetophenone SCHEMBL27985201 | 0.77 | MAPT (0.86) | MAPTSMN1; SMN2HDAC2LMNA | |
| Biphenyl SCHEMBL1555184 | 0.77 | MAPT (0.86) | MAPTSMN1; SMN2KMOHDAC2LMNA | |
| SCHEMBL7673881 | 0.76 | ACMSD (0.61) | MAPTSMN1; SMN2ACMSDHNF4AAKR1C2 | |
| SCHEMBL8103552 | 0.76 | HPGD (0.51) | MAPTSMN1; SMN2AKR1C3AKR1C2HDAC2 | |
| SCHEMBL8368648 | 0.76 | MAPT (0.83) | MAPTSMN1; SMN2ACMSDKMOHDAC2 | |
| Acetophenone SCHEMBL28342406 | 0.75 | MAPT (0.75) | MAPTSMN1; SMN2KMOHDAC2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077399-A1 | Substituted Azole Derivatives as Therapeutic Agents | TRANSTECH PHARMA, INC. (US) | 2011-03-31 | — | — | US | disclosed |
| CN-1747936-A | Substituted azole derivatives as therapeutic agents | TRANSTECH PHARMA INC (US) | 2006-03-15 | — | — | CN | disclosed |
| EP-1594847-A2 | SUBSTITUTED AZOLE DERIVATIVES AS THERAPEUTIC AGENTS | Transtech Pharma, Inc. (US) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004071447-A9 | SUBSTITUTED AZOLE DERIVATIVES AS THERAPEUTIC AGENTS | TRANSTECH PHARMA INC (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20040192743-A1 | Substituted azole derivatives as therapeutic agents | TRANSTECH PHARMA, INC. | 2004-09-30 | — | — | US | disclosed |
| WO-2004071447-A2 | SUBSTITUTED AZOLE DERIVATIVES AS THERAPEUTIC AGENTS | TRANSTECH PHARMA INC. (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192743-A1 | Substituted azole derivatives as therapeutic agents | PTPRS, PTPRO, PTPRJ | MAPT 3558/4885SMN1; SMN2 4575/4885ACMSD 3841/4885 |
| US-20110077399-A1 | Substituted Azole Derivatives as Therapeutic Agents | PTPRS, PTPRO, PTPRJ | MAPT 3558/4885SMN1; SMN2 4575/4885ACMSD 3841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.