Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20599739 | 0.86 | NAMPT (0.44) | JAK2CCR1CCR8CYP2A6SYK | |
| SCHEMBL16785592 | 0.81 | TGFBR1 (0.45) | PIM1CCR1CCR8CYP2A6MAPK1 | |
| SCHEMBL13680671 | 0.77 | CYP2A6 (0.44) | JAK2PIM1CCR1CCR8CYP2A6 | |
| SCHEMBL27090747 | 0.75 | TGFBR1 (0.44) | CCR1CCR8CYP2A6TGFBR1FGFR1 | |
| SCHEMBL13036040 | 0.75 | PRMT5 (0.47) | JAK2PDK2NAMPTPRMT5WDR77 | |
| SCHEMBL12269967 | 0.74 | CCR1 (0.52) | PIM1CCR1CCR8CYP2A6MAPK1 | |
| SCHEMBL885907 | 0.74 | L3MBTL1 (0.59) | JAK2PDK2MAPK1NAMPTKDM5B | |
| SCHEMBL30625193 | 0.74 | CCR1 (0.52) | PIM1CCR1CCR8CYP2A6MAPK1 | |
| SCHEMBL24289859 | 0.73 | CCR1 (0.50) | CCR1CCR8CYP2A6TGFBR1 | |
| SCHEMBL17795050 | 0.73 | NAMPT (0.48) | JAK2PDK2PIM1MAPK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344486-B1 | ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THEIR USE AS FAAH INHIBITORS | SANOFI SA (FR) | 2013-03-27 | — | — | EP | disclosed |