Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18484476 | 0.83 | NPSR1 (0.39) | NPSR1L3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14805664 | 0.83 | NPSR1 (0.39) | NPSR1L3MBTL1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6284882 | 0.78 | NPSR1 (0.47) | NPSR1LMNAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1096595 | 0.77 | ALDH1A1 (0.51) | NPSR1L3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL18193690 | 0.77 | NPSR1 (0.45) | NPSR1LMNAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1845956 | 0.73 | PIK3CA (0.45) | NPSR1LMNAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4120734 | 0.72 | LMNA (0.41) | NPSR1LMNAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30688636 | 0.71 | LMNA (0.47) | NPSR1LMNAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2952498 | 0.68 | CA1 (0.42) | NPSR1 | |
| SCHEMBL1431309 | 0.68 | NPSR1 (0.42) | NPSR1L3MBTL1SMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
| US-9481675-B2 | Gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20130079323-A1 | GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | NPSR1 4230/4885LMNA 981/4885L3MBTL1 1004/4885 |
| US-20130079323-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | NPSR1 4230/4885LMNA 981/4885L3MBTL1 1004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.