Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.45 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.45 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | AOC2 | O75106 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890356 | 0.90 | KDM4E (0.42) | ALDH1A1KDM4ELMNAMAPTKCNQ3 | |
| SCHEMBL14805911 | 0.84 | FAAH (0.40) | ALDH1A1KDM4ELMNAMAPTFAAH | |
| SCHEMBL16727321 | 0.81 | KCNQ3 (0.43) | ALDH1A1KDM4ELMNAMAPTKCNQ3 | |
| SCHEMBL11890339 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNAMAPTKCNQ3 | |
| SCHEMBL13677257 | 0.80 | CETP (0.39) | ALDH1A1KDM4ELMNAMAPTFAAH | |
| SCHEMBL13677287 | 0.80 | DPP4 (0.39) | ALDH1A1KDM4ELMNAMAPTFAAH | |
| SCHEMBL6042585 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNAMAPTNPC1 | |
| SCHEMBL5986894 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAMAPTNPC1 | |
| SCHEMBL10305114 | 0.79 | EPHX2 (0.49) | ALDH1A1KDM4ELMNAMAPTNPC1 | |
| SCHEMBL10146693 | 0.79 | ALDH1A1 (0.60) | ALDH1A1LMNAFAAHDPP4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481675-B2 | Gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20130079323-A1 | GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079323-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ALDH1A1 2837/4885KDM4E 1199/4885LMNA 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.