Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 5/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.49 |
| ▸ | GABRD | O14764 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29572015 | 1.00 | TDO2 (0.65) | TDO2CYP11B1CYP11B2PARP14IDO1 | |
| SCHEMBL28303023 | 0.94 | TDO2 (0.62) | TDO2CYP11B1CYP11B2PARP14IDO1 | |
| SCHEMBL28014781 | 0.91 | TDO2 (0.59) | TDO2CYP11B1CYP11B2PARP14IDO1 | |
| SCHEMBL29601793 | 0.84 | TDO2 (0.49) | TDO2PARP14IDO1HTR2BHTR5A | |
| SCHEMBL28782760 | 0.84 | TDO2 (0.49) | TDO2PARP14IDO1HTR2BHTR5A | |
| SCHEMBL28301583 | 0.84 | TDO2 (0.60) | TDO2CYP11B1CYP11B2PARP14IDO1 | |
| SCHEMBL26086391 | 0.83 | TDO2 (0.49) | TDO2PARP14IDO1HTR2BHTR5A | |
| SCHEMBL28852044 | 0.82 | IMPDH2 (0.53) | TDO2PARP14IDO1HTR2BHTR5A | |
| SCHEMBL191031 | 0.81 | CDK4 (0.55) | TDO2PARP14HTR2BHTR5AGABRP | |
| SCHEMBL29412285 | 0.81 | CDK4 (0.55) | TDO2PARP14HTR2BHTR5AGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790117-A | Carbazole benzene class fused-ring derivatives, polymer, mixture, composition, organic electronic device and preparation method thereof | 广州华睿光电材料有限公司 | 2019-05-21 | — | — | CN | disclosed |
| US-8362065-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-06-24 | — | — | US | disclosed |
| CN-100348594-C | Bidentate ligand and its iridium complex and electroluminescent device therewith | UNIV WUHAN (CN) | 2007-11-14 | — | — | CN | disclosed |
| CN-1680366-A | Bidentate ligand and its iridium complex and electroluminescent device therewith | UNIV WUHAN (CN) | 2005-10-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | TDO2 2235/4885CYP11B1 2255/4885CYP11B2 2304/4885 |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | TDO2 2235/4885CYP11B1 2255/4885CYP11B2 2304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.