Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 13/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15276725 | 1.00 | TRPM8 (0.73) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL15276692 | 0.92 | TRPM8 (0.75) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL15276695 | 0.92 | TRPM8 (0.75) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL14822024 | 0.85 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL30532217 | 0.85 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL14822017 | 0.85 | TRPM8 (0.53) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL1699243 | 0.85 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL1699240 | 0.85 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL30416175 | 0.85 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL15276661 | 0.83 | TRPM8 (0.64) | TRPM8ALDH1A1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | BASF SE (DE) | 2021-06-29 | — | — | US | disclosed |
| EP-2758041-B1 | LOW-MOLECULAR MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE OF SAME | BASF SE (DE) | 2021-01-13 | — | — | EP | disclosed |
| US-20190350239-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2019-11-21 | — | — | US | disclosed |
| US-10398159-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | BASF SE (DE) | 2019-09-03 | — | — | US | disclosed |
| US-20170265510-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2017-09-21 | — | — | US | disclosed |
| US-20170265510-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2017-09-21 | — | — | US | disclosed |
| US-20130251647-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2013-09-26 | — | — | US | disclosed |
| US-20130251647-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2013-09-26 | — | — | US | disclosed |
| WO-2013041621-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2013-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170265510-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 3977/4885SMN1; SMN2 4719/4885 |
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 3977/4885SMN1; SMN2 4719/4885 |
| US-10398159-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 3977/4885SMN1; SMN2 4719/4885 |
| US-20130251647-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 3977/4885SMN1; SMN2 4719/4885 |
| US-20190350239-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 3977/4885SMN1; SMN2 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.