Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.63 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14822024 | 1.00 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL30416175 | 1.00 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL1699240 | 1.00 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL30532217 | 1.00 | TRPM8 (1.00) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL20772855 | 0.87 | TRPM8 (0.76) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL29779963 | 0.87 | TRPM8 (0.76) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL15276692 | 0.85 | TRPM8 (0.75) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL15276695 | 0.85 | TRPM8 (0.75) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL14822014 | 0.85 | TRPM8 (0.73) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL15276725 | 0.85 | TRPM8 (0.73) | TRPM8ALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| EP-4725476-A2 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | Firmenich SA (CH) | 2026-04-15 | — | — | EP | disclosed |
| EP-4096714-B1 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | FIRMENICH & CIE (CH) | 2026-01-28 | — | — | EP | disclosed |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-12-25 | — | — | US | disclosed |
| EP-4608518-A1 | ORAL CARE COMPOSITIONS | Firmenich SA (CH) | 2025-09-03 | — | — | EP | disclosed |
| EP-4251122-B1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-03-12 | — | — | EP | disclosed |
| US-20250064063-A1 | ANTIMICROBIAL COMPOSITION HAVING ENCAPSULATED COLORANT | FIRMENICH SA (CH) | 2025-02-27 | — | — | US | disclosed |
| EP-3663366-B1 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2025-01-08 | — | — | EP | disclosed |
| US-20240307279-A1 | FAST DRYING PERFUME COMPOSITION | FIRMENICH SA (CH) | 2024-09-19 | — | — | US | disclosed |
| US-20240285512-A1 | ORAL CARE COMPOSITIONS | FIRMENICH SA (CH) | 2024-08-29 | — | — | US | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | SENOMYX INC (US) | 2016-12-29 | — | — | US | disclosed |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2015-03-26 | — | — | US | disclosed |
| US-8927605-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-20130202543-A1 | USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT | SYMRISE AG (DE) | 2013-08-08 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| EP-2501761-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | Symrise AG (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | TAS2R5, TAS1R1, TAS2R1 | TRPM8 70/4885ALDH1A1 1490/4885SMN1; SMN2 2390/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | TRPM8 1/4885ALDH1A1 3726/4885SMN1; SMN2 2480/4885 |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | TAS2R30, TAS2R1, TAS2R20 | TRPM8 165/4885ALDH1A1 540/4885SMN1; SMN2 651/4885 |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 2466/4885SMN1; SMN2 4426/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | TRPM8 97/4885ALDH1A1 1029/4885SMN1; SMN2 2225/4885 |
| US-20130202543-A1 | USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT | CUTA, MCOLN2, MCOLN3 | TRPM8 10/4885ALDH1A1 1673/4885SMN1; SMN2 4076/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885ALDH1A1 3880/4885SMN1; SMN2 2345/4885 |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 2466/4885SMN1; SMN2 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.