SCHEMBL14822066

SCHEMBL14822066

CC(C)(C)c1cc(CNc2nc(N)nc(-c3ccccc3)n2)cc(C(C)(C)C)c1O

nearest known ligand 0.64

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.64
GPR68 Q15743 5/20 0.57
HTR1A P08908 1/20 0.57
TPH1 P17752 11/20 0.51
ADORA2A P29274 3/20 0.46
HTR2B P41595 1/20 0.46
ADORA1 P30542 2/20 0.42
POLB P06746 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
ADORA2B P29275 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14822067 0.91 NPSR1 (0.49) NPSR1GPR68HTR1ATPH1ADORA2A
SCHEMBL14822455 0.85 GSR (0.50) NPSR1POLB
SCHEMBL14822456 0.85 GSR (0.50) NPSR1POLB
SCHEMBL15959816 0.82 NPSR1 (0.41) NPSR1GPR68HTR1ATPH1ADORA2A
SCHEMBL14822458 0.77 GSR (0.57) NPSR1POLB
SCHEMBL197517 0.73 NPSR1 (0.71) NPSR1GPR68HTR1ATPH1ADORA2A
SCHEMBL6269189 0.73 NPSR1 (0.71) NPSR1GPR68HTR1ATPH1ADORA2A
SCHEMBL29015812 0.73 GSR (0.53) NPSR1
SCHEMBL723446 0.72 NPSR1 (0.61) NPSR1GPR68HTR1ATPH1ADORA2A
SCHEMBL17840534 0.72 NPSR1 (0.73) NPSR1GPR68HTR1ATPH1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020058337-A1 USE OF A MELAMINE BASED COMPOUND AND A HALS COMPOUND AS HEAT STABILIZER IN POLYMERS BOREALIS AG (AT) 2020-03-26 WO disclosed
EP-3626772-A1 USE OF A MELAMINE BASED COMPOUND AND A HALS COMPOUND AS HEAT STABILIZER IN POLYMERS Borealis AG (AT) 2020-03-25 EP disclosed
EP-2758462-B1 STABILIZING OF ORGANIC MATERIAL WITH AMINO-TRIAZINE BASED MANNICH-COMPOUNDS BOREALIS AG (AT) 2018-03-07 EP disclosed
US-9546261-B2 Stabilizing of organic material with amino-triazine based mannich-compounds BOREALIS AG (AT) 2017-01-17 US disclosed
US-9546261-B2 Stabilizing of organic material with amino-triazine based mannich-compounds BOREALIS AG (AT) 2017-01-17 US disclosed
US-20140235766-A1 Stabilizing of Organic Material with Amino-Triazine Based Mannich-Compounds BOREALIS AG (AT) 2014-08-21 US disclosed
US-20140235766-A1 Stabilizing of Organic Material with Amino-Triazine Based Mannich-Compounds BOREALIS AG (AT) 2014-08-21 US disclosed
WO-2013041592-A1 STABILIZING OF ORGANIC MATERIAL WITH AMINO-TRIAZINE BASED MANNICH-COMPOUNDS BOREALIS AG (AT) 2013-03-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140235766-A1 Stabilizing of Organic Material with Amino-Triazine Based Mannich-Compounds PCNA, SOD1, UBE2M NPSR1 2224/4885GPR68 1913/4885HTR1A 3109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.