Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023183 | 0.86 | MEN1 (0.35) | APP | |
| SCHEMBL14666702 | 0.81 | ALOX5 (0.31) | — | |
| SCHEMBL3019474 | 0.80 | NR3C2 (0.42) | TSHRMAPT | |
| SCHEMBL3029492 | 0.77 | DGAT1 (0.33) | — | |
| SCHEMBL3027011 | 0.75 | RIPK2 (0.32) | — | |
| SCHEMBL3030882 | 0.73 | AR (0.32) | — | |
| SCHEMBL13430988 | 0.70 | PTGS1 (0.32) | HTTMAPTAPP | |
| SCHEMBL3027955 | 0.69 | APP (0.34) | NPC1RAB9AMAPTAPPSMN1; SMN2 | |
| SCHEMBL30507312 | 0.69 | ACHE (0.48) | APPFFAR4MAPK14 | |
| SCHEMBL3030497 | 0.69 | NR3C2 (0.41) | TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410166-B2 | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-04-02 | — | — | US | disclosed |