SCHEMBL14823262

SCHEMBL14823262

Cc1ccc(-c2cc(=O)n3[nH]c(Cc4ccccc4)c(-c4ccc(Cl)cc4)c3n2)cc1

nearest known ligand 0.88

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PSD A5PKW4 17/20 0.88
SLC27A2 O14975 1/20 0.76
MAPT P10636 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29519105 0.86 PSD (1.00) PSDSLC27A2
SCHEMBL28357395 0.64 MEN1 (0.72) MAPT
SCHEMBL15708521 0.63 KDM4E (0.64) PSDMAPT
SCHEMBL24733679 0.62 TP53 (0.51) PSDSLC27A2MAPT
SCHEMBL11299394 0.61 CYP1A2 (0.47) MAPT
SCHEMBL9705307 0.61 NPC1 (0.51) MAPT
SCHEMBL2868702 0.61 NR1H2 (0.56) PSDMAPT
SCHEMBL8099805 0.60 NPC1 (0.58) MAPT
SCHEMBL18931772 0.60 GSK3B (0.64)
SCHEMBL13325723 0.60 ALDH1A1 (0.59) PSDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8431582-B2 Inhibitors of fatty acid uptake and methods of use NUTECH VENTURES (US) 2013-04-30 US disclosed
US-8410118-B2 Inhibitors of fatty acid uptake and methods of use NUTECH VENTURES (US) 2013-04-02 US disclosed