Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 7/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1231896 | 0.88 | SLC22A12 (0.56) | MAPK14KDM1ACA1CA2SLC22A12 | |
| SCHEMBL2428847 | 0.84 | MAPK14 (0.52) | MAPK14ALDH1A1KDM1AMAP4K4 | |
| SCHEMBL2039607 | 0.81 | SLC22A12 (0.53) | MAPK14SLC22A12MAP4K4 | |
| SCHEMBL17855536 | 0.80 | MAPT (0.48) | ALDH1A1MAPTHSD17B1KDM1ACA1 | |
| SCHEMBL10058042 | 0.79 | MAPT (0.66) | ALDH1A1MAPTHSD17B1CA1CA2 | |
| SCHEMBL163209 | 0.77 | ALDH1A1 (0.72) | ALDH1A1MAPTCA1CA2 | |
| SCHEMBL1140572 | 0.76 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL10110951 | 0.76 | ALDH1A1 (0.56) | MAPK14ALDH1A1KDM1A | |
| SCHEMBL27885275 | 0.76 | HSD17B1 (0.44) | MAPK14MAPTHSD17B1 | |
| SCHEMBL2345404 | 0.76 | HRH2 (0.47) | MAPK14ALDH1A1MAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021328-B1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2013-04-03 | — | — | EP | disclosed |